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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophy, according to Professor Walpola. However, in the end it caused muscle deterioration and damage. Researchers at McMaster University in Hamilton, Ontario, say that the number of patients being studied has shrunk significantly since the start of the project. Researchers are now recruiting for the clinical trials, which will start next year, and hope to take part as soon as 2016. They will then expand the study to more than 500 participants and see if the therapy is superior to conventional treatments. "We want to know whether the use of LDPE improves the outcomes and if it is able to maintain the benefits that we have experienced with the older people in this study," Professor Walpola told Reuters Health by phone. LDPE is currently used to treat osteoporosis, diabetes and depression in the elderly. Dr Arieh Keshavarz, a senior author of the study and director of McMaster's Centre for Geriatric Gerontology and Geriatrics Research, says LDPE has long been considered the standard treatment for age-related muscle weakness. In the study Keshavarz and co-author Professor Roshni Patel, found that even patients who never have used LDPE for a medical condition suffered significant loss of strength with exercise without losing muscle mass. "If LDPE is used to treat this condition, it will not only improve the recovery and the maintenance of strength and muscle mass but also improve the quality of life in the elderly people and for the prevention of future disease," the researchers said in a statement. SOURCE: bit.ly/2bHvKfV McMaster University press release Researchers investigate ways to extend the lifespan of geriatric patients with muscle weakness caused by muscle atrophy. "We found that over a month after the patients began exercising they gained strength and had lost their previous muscle mass," said Dr Arieh Keshavarz, McMaster University Associate Professor in Geriatric Gerontology and Geriatrics Research. "This was probably due to the improvement in the quality of life of the patients that we treated." Professor Patel, a McMaster University associate professor in the Department of Internal Medicine and Geriatrics and a clinical research fellow at McMaster, said the results were encouraging and have opened new doors for treatment of muscle atrophy in the elderly. "We believe that this will open the doors for more effective treatments for people that are experiencing muscle atrophy through aging," she said in a statement. Similar articles: